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If successful, these compounds would bring the higher efficacy of dual-agonist therapy (demonstrated by tirzepatide) into an oral format

This conservative approach has merit because it keeps a higher dose in reserve as a strategic tool

This would require daily or multiple daily injections impractical for patients and physicians

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These results proved the critical role of -syn pathology in chronic hypoxia-afforded cognitive impairment and revealed a novel mechanism underlying -syn hyperphosphorylation during chronic hypoxia

[DOI] [PMC free article] [PubMed] [Google Scholar] 303.Barth, P