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Appl Microbiol Biotechnol 97(20):91559164

Recombinant human GPX4 alleviated ISO-induced myocardial ischemia injury [250]

It creates new blood vessels (VEGF) to deliver nutrients, accelerates collagen synthesis for stronger cartilage, and stabilizes cellular membranes to stop joint deterioration

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Glycine or glycine-based treatments [e.g., serine, trimethylglycine (betaine) and a glycine-based tripeptide, DT-109] lowered hepatic steatosis, inflammation and fibrosis as well as atherosclerosis in various rodent models (83, 195, 227) and humans (199) through mechanisms involving hepatic GSH biosynthesis, enhanced fatty acid utilization, suppression of proinflammatory/fibrotic responses and modulation of the gut microbiome

Occasionally, a pattern of associated lichenoid dermatitis is observed, with CD3+, CD8+ T lymphocytes, more evident in perilesional skin