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Careful patient selection is essential
However, the specific metabolic checkpoints of the altered thresholds need further exploration, which is a future research direction

Clinicians are urged to exercise caution and to proactively counsel patients who may be using these products without disclosure

doi: 10.1016/j.metabol.2021.154886 118 SkjaerbaekCFrystykJOrskovHKissmeyer-NielsenPJensenMBLaurbergSet al

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Because it is often in short supply, it is considered the "rate-limiting" factor
