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[DOI] [PubMed] [Google Scholar] 17.Brown DA, Jew KN, Sparagna GC, Musch TI, Moore RL

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This regulation was shown to occur under the direct transcriptional control of GA-binding protein alpha (GABPA)a critical Ets-family transcription factor that acts as a master regulator of mitochondrial biogenesis by controlling the expression of nuclear-encoded mitochondrial proteins, and whose direct binding to the PHB2 promoter makes it a key upstream determinant of the cells capacity for mitophagy (60)

e071725e071725, www.bmj.com/content/383/bmj-2022-071725, Dangour, Alan D, et al

Mitochondria: Structure, function, and pathophysiology Mitochondria are the double membrane, cytoplasmic organelles which contain their self-replicating genome