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To that end, DHEA may:6 Interact with prescription medications (particularly those for mental health, including SSRIs, antipsychotics, carbamazepine, lithium, and valproic acid) Worsen psychiatric disorders and increase the risk of mania in people with mood disorders Reduce HDL (good) cholesterol levels Increase the risk of hormone-sensitive cancers (prostate, breast, and ovarian) Lead to oily skin, acne, or hirsutism in women (male-pattern hair growth) For more information on the potential drug interactions, you can find extensive lists from the Mayo Clinic and Mount Sinai

[DOI] [PubMed] [Google Scholar] Maebashi M, Kawamura N, Sato M, Imamura A, Yoshinaga K

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PMID: 35334912

10.1007/s002030100272

identified PERK as a specific receptor for TMAO, demonstrating that TMAO directly activates the PERK branch of the UPR at physiological concentrations, thereby inducing the transcription factor FoxO1, which is implicated in metabolic and inflammatory diseases (81)