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They found that GFAP consistently detected mild to moderate TBI, predicted CT lesions, and neurosurgical intervention over 7 days, while UCHL1 acted as an early marker [96]

Nanoparticle-based delivery systems, including lipid-based carriers such as liposomes and niosomes, as well as polymeric nanoparticles like chitosan and PLGA, offer promising solutions

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REDEFINE 1 and REDEFINE 2 ran 68 weeks, with the first ~16 weeks dedicated to dose titration

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Western blot analysis Western blotting was performed as previously described via the following antibodies: FBXO22, BACH1, KLF4, LKB1, SNAL1, PTEN, KDM4A, BAG3, and GAPDH (all from Proteintech, Rosemout, IL)