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The mitochondrial membrane permeabilization results in the release of the proapoptotic factors from the mitochondrial intermembrane space, cytochrome c [194], AIF [195], and endonuclease G [196], to the cytosol
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Because NNMT is involved in basic metabolic processes, 5-Amino-1MQ is often used as a research tool to reduce NNMT activity in controlled experimental systems
