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Due to the relatively constitutive activity and the membrane permeability of H 2 O 2 , NOX4-derived signals can integrate across subcellular compartments to modulate transcriptional responses for adapted metabolic homeostasis [32, 33]
While positive advances have been made, there have been reports of adverse effects leading to autoimmune pathologies (174)
Rats treated with arctigenin had no VF during reperfusion and markedly enhanced activities of SOD and GPx, as well as reduced MDA levels
PMID: 11576348 25
doi: 10.1126/science.1198469 90 ReadSMalmstrmVPowrieF
