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Candesartan inhibits carotid intimal thickening and ameliorates IR in balloon-injured diabetic rats

132 Romay-TallonR.Dopeso-ReyesI

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Blood collected prior to the morning feeding on day 0, 28, and 56 was analyzed for hydrogen peroxide (H 2 O 2 ) production and concentration, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, concentrations of malondialdehyde (MDA), cytokines [interleukin (IL)-4, IL -6, IL -8, IL -10 and tumor necrosis factor ], and caffeine, and mRNA expression of IL -1 , Nrf2 , and HMOX1