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These mutations may arise from internal sources, such as DNA replication errors or inherited genetic variants, as well as external factors like chemical toxins, radiation, and infections

Therefore, regardless of the presence of neurological symptoms, SCD should be suspected in patients with skin hyperpigmentation, as the neurological manifestations can be a late finding [2]

Kaelberer MM, Buchanan KL, Klein ME, Barth BB, Montoya MM, Shen X, Bohrquez DV (2018) A gut-brain neural circuit for nutrient sensory transduction

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Overall, these data support the human observations and show increased zonulin levels, reduced TJ protein complex expression and impaired intestinal barrier function preceding the onset of arthritis

Accelerated recovery from minor skin injuries