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Susceptibility [to absorbing the nutrient] varies, so if you take B6 supplements, you really should have a medical professional check your blood levels to make sure theyre not in excess. A peer-reviewed article provides more information about toxicity
Kalchofner Guerrero KS, Campagna I, Bruhl-Day R, Lanza Perea M, Hegaman-Younger C, Guerrero TG (2015)

In: Andersen, F.L

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Conversely, the presence of T877 limits the pocket size and is thought to be important for ligand specificity
