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Free ionic copper is toxic and tightly regulated in biological systems, but copper delivered as a peptide chelate bypasses those restrictions, allowing localized delivery to fibroblasts and keratinocytes without systemic copper overload

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In other tissues, including the liver, skeletal muscle and macrophages, genetic disruption of clock genes has also been linked to changes in CI, CII and CIII respiration 6,37,38,39,40,41,42,43 , highlighting that clock regulation of mitochondrial function is shaped by cell type and metabolic state