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These negative regulatory mechanisms limit the pro-inflammatory effects of IL-6 under normal physiological conditions but may be disrupted in chronic neuroinflammatory states, leading to a sustained inflammatory response (166, 167)

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Another Phase I trial (NCT04629404) was conducted on early-stage PD patients to assess pharmacokinetics, pharmacodynamics, and safety of LY03003, demonstrating well tolerability and promising pharmacodynamic effects, suggesting its suitability for continuous dopaminergic stimulation 141