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Reductive carboxylation supports redox homeostasis during anchorage-independent growth

ChaC2 induces mitochondrial apoptosis and autophagy via UPR, serving a pivotal role as a tumor suppressor gene in the onset, proliferation and metastasis of gastric and colorectal cancer (79)

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doi: 10.1016/S0014-5793(99)00372-5 215 AroraDJainPSinghNKaurHBhatlaSC

Overall, natural compounds show minimal systemic or organ toxicity at therapeutic doses, although mild side effects may occurcurcumin, for instance, has resulted in only minor gastrointestinal upset even at high doses [22, 30, 57]