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Lastly, research has shown that utilizing an M2-targeting peptide-modified liposome carrier for YY1-targeted therapy in M2 macrophages is highly effective in inhibiting PCa cell lung metastasis and exhibits synergistic antitumor effects when combined with PD-1 blockade (Tsang et al., 2020)

Jumping directly to the maintenance dose significantly increases the risk of gastrointestinal side effects

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Although most of the early experiments using cuprizone were conducted in mice, a number of studies demonstrated detrimental effects of cuprizone administration to the brain similar to those in mice of other rodents, such as rats [3135], guinea pigs [31] or hamsters [36, 37]

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