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However, it's important to contextualize this assessment within the limitations of the available evidence: most safety data comes from relatively small studies, often of short-to-moderate duration, conducted primarily in the Soviet Union, Russia, and Eastern Europe where methodological standards and reporting practices have sometimes differed from Western pharmaceutical trial requirements

Elevated Energy Expenditure Preclinical findings demonstrate higher energy expenditure and greater fat oxidation in obese models

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[PubMed] [Google Scholar] 192.Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, Defronzo RA, et al

A: It depends on the regulatory body

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