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Neuroinflammation, in which microglia and astrocytes take on an inflammatory phenotype and secrete toxic factors such as cytokines and nitric oxide, is another major component of neurodegenerative disease [57, 58]

Finally, we briefly describe how the GH/IGF-I axis is impacted by liver disease, weight loss, GH misuse for recreational and athletic performance-enhancing, GH-releasing hormone (GHRH) analog use in HIV lipodystrophy, and the alterations of the GH/IGF-I axis in subjects with congenital isolated GH and IGF-I deficiencies

Tian Y, Yang B, Qiu W, Hao Y, Zhang Z, Yang B, et al

Therefore, HSF1 and HSF2 could represent a marker to identify the accumulation of damaged proteins and the induction of cell death [90]

A., Goedert, J

Additionally, it clears metabolic byproducts that could interfere with normal cellular signaling, helping cells function more efficiently