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The impaired cross-talk between dysfunctional endothelial cells and fibroblasts further compromises angiogenesis, as endothelial cells provide critical paracrine signals (such as PDGF-BB) that recruit and activate fibroblasts, while fibroblasts produce VEGF and deposit the ECM scaffold necessary for endothelial tube formation

PLoS ONE 2024;19: e0307212

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The effect of ascorbic acid on adrenal steroid synthesis in Vitro

However, evidences emerged so far in this regard are contradictory, with some reports indicating the role of seleno-GPxs in offering radioresistance, while others rejecting such claims

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