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Thus, targeting VEGF/VEGFR to improve vascular dysfunction - a process known as vascular normalization - not only inhibits the sprouting of new vessels [69], but it may also normalize the vasculature and improve the delivery and efficacy of anticancer drugs, improve oxygen levels, and overcome immunosuppression [70]

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Pharmacovigilance analysis identified that patient age and body weight were significantly associated with gastrointestinal adverse event severity, with patients over 100 kg showing stronger signal strength for adverse events