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doi: 10.1039/D1FO01963E 13

Data was normally distributed and all statistical analyses and graphs were carried out using GraphPad Prism (version 4.0, GraphPad Software, Inc.) and SigmaPlot (version 12.5, Systat software, Inc.)

399 They can penetrate the cell membrane by themselves and effectively enhance the intracellular delivery of NADs, aiding their interaction with the target to achieve therapeutic goals

Figure 3 ALA considerably suppresses CSD-induced inflammatory reaction As shown in Figure 4, CSD significantly induced hepatic inflammation by noticeably up-regulating NF-B-mediated inflammatory reaction, and increased the production of several key inflammatory factors such TNF-, IL-1, IL-6, and COX2 in hepatic tissues as examined by both immunohistochemical (Figures 4B,E,H) and biochemical approaches (Figures 4J,K)

Epigenetic mechanisms of endocrine- disrupting chemicals in obesity

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