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Having a gene variant doesnt mean it causes disease

Dermatological effects: Less frequently, patients may experience mild skin reactions, such as a temporary rash or pruritus (itching)

This triggers the MAPK cascade, such that Ras-GTP activates Raf [also called MAPK kinase kinase (MAPKKK)], which in turn activates MEK1/2 [MAPK kinase (MAPKK)]

doi: 10.1002/mus.20840
Selenium deficiency risk predicted to increase under future climate change
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A moderate increase in protein intake, along with low salt and sugar intake, has been identified as a possible lifestyle change that can help lower high blood pressure