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This Review provides an overview of UPS-mediated proteostasis, focusing on the involvement of the UPS in renal physiology and pathophysiology.

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and mot...

In addition, interactions between essential and toxic metals involve both competitive and protective mechanisms that influence metal uptake, transport, and detoxification