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There is a need for comprehensive risk assessments and safety regulations to mitigate adverse reactions in humans and animals (58)

[DOI] [PMC free article] [PubMed] [Google Scholar] 196.Zeng W.-Y., Tan L., Han C., Zheng Z.-Y., Wu G.-S., Luo H.-R., Li S.-L

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Juvenile Animal Data Studies conducted in juvenile rats and dogs at clinically relevant doses showed growth suppression that partially or fully reversed in dogs and female rats but not in male rats after a four-week drug-free recovery period

Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation

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