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Notably, accumulating evidence indicates that DMF also exerts immunomodulatory effects through NRF2-independent mechanisms

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This systemic effect may explain why users sometimes report benefits beyond the specific area being treated

Such people often suffer from hearing loss, tinnitus, and problems with pitch perception

moreover, in those with heart failure, decreasing DHEA-S levels were correlated with increasing heart failure severity

[DOI] [PMC free article] [PubMed] [Google Scholar] 244.Hornedo-Ortega R., Alvarez-Fernandez M.A., Cerezo A.B., Richard T., Troncoso A.M.A., Garcia-Parrilla M.A.C