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Serious B12 deficiency may cause anemia and nerve damage

Nature 392 , 677684 (1998)

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Once activated by their ligands, they undergo a conformational change, promoting their release from chaperone proteins and facilitating their dimerization and translocation to the nucleus, where they bind to specific regions of DNA called hormone response elements, to recruit co-regulators, chromatin remodelers, and the transcription machinery [for review (63, 64)]

Effects of varieties and growing conditions on antioxidant capacity of coffee