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However, tirzepatide has a larger, more complex structure (39 amino acids with a C20 fatty acid moiety vs

Previous studies have demonstrated that reduced input resistance is characteristic of strongly burst firing neurons (Williams and Stuart, 1999), suggesting that an increase in input resistance may be responsible for the decrease in the number of spikes in bursts

doi: 10.3389/fimmu.2018.01873

Miura, Y

Heparanase is essential for the development of diabetic nephropathy in mice
