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NAD+ is a direct substrate replenishing cellular pools (low oral bioavailability), whereas 5-Amino-1MQ is an NNMT enzyme inhibitor protecting existing NAD+ from degradation

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Greibe E, Lildballe DL, Streym S, et al

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Dont Drown Your Sorrows (or Joys) in Alcohol While celebrating your B12 shot or unwinding after a long week might involve a drink, its best to avoid alcohol for at least 48 hours after your injection

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If cold sensations are particularly bothersome, your clinician or study team may consider adjusting the dose escalation schedule a common approach with GLP-1-based therapies where tolerability issues arise

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