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In the case of compound 5 , we observed a hydrogen bond between the amino group of the fragment and a backbone carbonyl in the neighbouring protein chain (Fig

Independent of loss of kidney function, a rise in BUN may also occur as a result of hypercatabolism from the excess breakdown of amino acids

Eculizumab, a murine humanized monoclonal antibody inhibiting C5 [360], underwent evaluation in the COMPLETE study, a prospective, double-masked, randomized phase 2 clinical trial with 30 GA patients

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