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Autophagy-associated pathways induce an excessive degradation of ferritin, leading to an increase in the amount of free iron in neurons

By using the passive and/or active strategies for BBB regulation and crossing in a controlled and non-invasive manner, various drug delivery systems are engineered to facilitate the brain-targeted delivery of specific therapeutics including small-molecule drugs, proteins, genes, and other biopharmaceutics

Upon the metastasis of breast cancer cells to the brain tissue, the challenge is the delivery of drugs to the brain

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