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Interestingly, despite the activation of anabolic pathways, CSCs also activate catabolic lipid pathways, such as fatty acid oxidation (FAO)

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In two pivotal phase III trials (NCT00420212 and NCT00451451), dimethyl fumarate (DMF, 240 mg twice daily) significantly reduced the annualized relapse rate, MRI lesion activity, and disability progression relative to placebo, with a safety profile dominated by transient flushing and gastrointestinal symptoms

It is important to mention that although the elderly group receives a small dose of CoQ10, it is administered in conjunction with transcutaneous electrical acupoint stimulation (Qi et al., 2022)

Transcript usage and alternative splicing events were measured as PSIthat is, for a given event, the total estimated counts for transcripts including the event were divided by the total estimated counts for all transcripts that could include the event