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If you dont have enough B12, you can end up developing a certain kind of anemia known as megaloblastic anemia

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doi: 10.1007/s00415-020-10081-5

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In the susceptible ecotype the induction of these defense-related genes was clearly delayed as compared to the resistant one (Ho and Yang, 1999)

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Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas

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The binding of amino acids increases the solubility of these metabolites

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2012 Dec;32(6):797-803

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