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The STAT3 factors induce the expression of SOCS proteins which consequently inhibit the function of JAK/STAT3 signaling, i.e., SOCS proteins exert a negative feedback on the JAK/STAT3 signaling induced by both insulin/IGF-1 and certain cytokine pathways

doi: 10.1186/s12957-023-03176-6 71 ShaoJBaiZZhangLZhangF

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Recent human studies shed light on how direct GSH supplementation performs: In a 6-month, blood and lymphocyte GSH increased 3035%, with buccal cell levels rising 260% and oxidative stress markers dropping