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Recently, in 2016, a phase 2 trial (N = 332 LOE1a) showed that daily administration of 1500 mg LC or mecobalamin resulted in significant reductions in neuropathy symptom score and neuropathy disability score in diabetic patients
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36, 37 Its protective role has been ascribed to the ability to inhibit the activation of the caspase cascade

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He is survived by his loving brothers, Norman Shifflett and Gary Shifflett