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V.MalyutinaS.RyabikovA.SchirmerH.et al (2023)

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Alternatively, diet-induced weight reduction can reverse ghrelin resistance, which is a defence mechanism to maintain a higher body weight set-point established during periods of food availability, maximizing energy reserves during periods of food scarcity [139]

342,343,344 The GLP-1R signaling pathway may also affect the expression of MMP-13 and ADAMTS5, by reducing the signal transduction caused by IL-1, thus decreasing their synthesis