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Fluctuations in the hormones estrogen and progesterone are the main culprits, as they can stimulate pigment-producing cells (melanocytes) to overproduce melanin

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These athletes were selected based on their high skill level, as all participants held a Russian master-level swimming certification, ensuring they had the necessary training and competitive experience for the experimental protocols

Augsburger JJ, Brooks CC, Correa ZM

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It is likely that, because of the very early loss of permanent dentition and the high likelihood of tumour recurrence, final rehabilitation of this infant's dentition will require a long-term, multidisciplinary approach involving costly interventions