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Studies show that under conditions of low GPX4 expression, DHODH effectively suppresses mitochondrial lipid peroxidation and ferroptosis

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In vivo experiments showed the peptide rapidly restoring blood flow through collateral vessel activation in models of venous occlusion, an effect closely linked to the NO system and reduction of free radical formation

[DOI] [PMC free article] [PubMed] [Google Scholar] [170].Wirawan E, Vanden Berghe T, Lippens S, et al

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Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays