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No difference in the need for definitive therapy was observed
Hyperalgesia can be assessed with sufficiently sharp pin prick testing over the affected site, and if a patient reports exaggerated pain, this finding would suggest the presence of hyperalgesia

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J Neural Transm 112:789796 Ueno Y, Koike M, Shimada Y, Shimura H, Hira K, Tanaka R, Uchiyama Y, Hattori N, Urabe T (2015) l-Carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain
