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Limited mutation analysis data are available but it is essential to determine the underlying mutations to learn more about the functional properties of the mutant enzyme

The role of NLRP3 inflammasome in infection-related, immune-mediated and autoimmune skin diseases

323 Oxidative stress promotes the Th2 type immune response by inducing Th1 cell apoptosis and Th2 cell differentiation, breaking the Th1/Th2 balance, and causing Th2 airway inflammation

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For example, multiple studies have shown that the levels of ferritin in the CSF of patients with AD are elevated and this increase is associated with faster rates of cognitive decline and brain atrophy, suggesting that CSF ferritin levels could be a valuable prognostic biomarker (77,78)