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Subsequently, a QTL analysis was conducted using the composite interval mapping (CIM) method, employing FCG and FCC indexes

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Key pathways such as PI3K-AKT-mTOR, LKB1-AMPK, E-cadherin-Hippo-YAP/TAZ, and VHL-HIF critically modulate ferroptosis in cancers via metabolic regulation and stress-response mechanisms ( In the future, integrating strategies to target ferroptosis defense pathways and enhance the efficacy of cancer immunotherapy will represent a promising therapeutic approach

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