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A typical treatment for deficiency starts with three injections over two weeks, then maintenance shots every one to three months, depending on the cause

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Denosumab works differently than bisphosphonates

Payers accept it temporarily, but flag repeated use for audit and may reimburse at lower rates

The elimination of drug from tissue distribution depends largely upon the ability of binding sites in the circulation to carry it to the liver where it is metabolized

Patients with severe MTHFR deficiency (0-20% residual enzyme activity) in infancy or adolescence present with developmental delay, severe mental retardation, motor and gait dysfunction, seizures, psychiatric disturbances, and other neurological abnormalities