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The C-to-U editing of the APOB mRNA requires a single-stranded RNA template with well defined characteristics in the immediate vicinity of the edited base, as well as protein cofactors that assemble into a functional complex referred to as a holoenzyme or editosome

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15 : 117132 Smith CD, Gallenstein LG, Layton WJ, Kryscio RJ, Markesbery WR

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Gerton, B Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial Arch Neurol 69 1: 29-38

doi: 10.1002/phar.2017 [PubMed] 29666958 Osman GM, Arajo DF, Maciel CB