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Another systematic review in children, based on limited evidence from a single, methodologically weak randomized controlled trial, suggested that the parenteral route is more efficacious than the oral route (218)

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Nrf2 translocates to the nucleus and interacts with the antioxidant response element (ARE) of target genes, resulting in expression of antioxidant genes, which induces an antioxidant response shown to be beneficial for several human conditions 48

Targeting -glutamyltransferases (e.g., with GGsTop) prevents GSH catabolism, reduces cysteine supply, and limits tumor growth highlighting a promising therapeutic angle.