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AgRP neurons do so through projections to the paraventricular hypothalamus (PVH), where, in a mechanism not previously described for AgRP neurons, they presynaptically inhibit the terminals of tonically active GABAergic afferents from the bed nucleus of the stria terminalis (BNST) that otherwise restrain activity of corticotrophin-releasing hormone (CRH)-expressing neurons

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Butyrate, a short chain fatty acid abundant in the gut after the bacterial fermentation of carbohydrates, also induces tight junction assembly of ZO-1 and occludin through an AMPK-dependent pathway 82

Medicinal Chemistry 66, 677694

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