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Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse

SILVERBLATT, F.J

This innovative strategy aims to verify CD38 expression and to stratify patients for daratumumab therapy, thereby reducing off-target toxicities and avoiding unnecessary treatment of individuals unlikely to respond

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While the precise mechanism underlying CD38 upregulation in these pathological conditions and disease models are not fully understood, CD38-mediated NAD + consumption leading to NAD + decline and consequent loss of cellular sirtuin activity appears to be a universal mechanism underlying their pathogenesis 24,31