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Consequently, therapeutic strategies aimed at reversing immunosenescencethrough the elimination of senescent cells (senolytics), neutralization of the SASP, or epigenetic rejuvenation (e.g., with DNMTis or HDACis)represent a novel and complementary frontier in glioma therapy

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122 NiidaA.HirokoT.KasaiM.FurukawaY.NakamuraY.SuzukiY.et al (2004)

As emphasized, although not specifically investigated in the glaucoma rats, the recently described activation of the Src-Caveolin-1-eNOS pathway [103,104] and interaction with several molecular pathways [103,104,107,108,109,110,111,112,113,114,115] may be important for maintaining vasomotor tone, and thereby essential for prompt therapeutic effect in glaucoma rats

Acts partially through local GI mucosal pathways and partially via systemic absorption