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It may help to increase the breakdown of fat in the body and improve the use of fat as an energy source

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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

While it often does not cause bleeding, untreated gastritis can irritate the lining enough to cause small bleeds, leading to melena

For a recent review on TMAO and its links to diet and the microbiome see this review
