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Treatment of bone marrow-derived macrophages with ML162, a GPX4 inhibitor, increased the amounts of oxidized phospholipids, such as PE, phosphatidylserine (PS), and phosphatidylinositol (PI) 43

doi: 10.3748/wjg.v13.i38.5127

Evolution of the Met-dependent disulfide reductase system To date, the Met-dependent disulfide reductase system has been studied only in mice, so its evolutionary history can only be inferred

First, the protein has no characteristic absorption peak in the THz band

A combinatorial library of biodegradable lipid nanoparticles preferentially deliver mRNA into tumor cells to block mutant RAS signaling

Along that line, we show catalytically inactive SnCE1 C256A inducing mitochondrial fragmentation to some extent similar as observed for wild type SnCE1, suggesting this phenotype may be elicited independently from its catalytic activity, maybe by having a dominant-negative effect