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Tolllike receptor (TLR) stimulation and neutrophil extracellular trap (NET) development are two intrinsic immune pathways that exacerbate tissue injury and swelling (Winchester et al

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Importantly, iron accumulation within microglia drives them toward a pro-inflammatory M1 state, which not only exacerbates neuroinflammation and DA neuronal loss but also establishes a vicious cycle involving inflammasome activation and ferroptosis (Yu et al., 2023)

Since the growth and development of tumors depend on the intake of foreign amino acids, more and more studies have targeted the metabolism of tumor-related amino acids to selectively kill tumor cells

However, this phenotype indicates that unregulated GSH synthesis or high levels of GSH may disrupt certain critical aspects of development