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Preclinical evidence Mice with a deletion of the 22q11.2 locus containing most proteins expressed in mitochondria [19] show increased cytoplasmic 8-oxo-2-deoxyguanosine (suggesting mitochondrial DNA oxidation), reduced number of PV-immunoreactive interneurons, and weakened PNN in anterior cingulate cortex [15]

Payapwattanawong S, Osterlund E, Vetere G, Bent AH, Dasari A, Kee BK, Parseghian C, Willis J, YC Shen JP, Singh Raghav KP, Eluri M, Morelli MP, Overman MJ, Le P, Huey RW, Martinez SA, Higbie V, Shen X, Van K Morris II, Kopetz S

In fact, the levels of several of the metabolites in the TSP and OCM pathways differed between individuals with ALD, active drinkers without liver disease, and healthy controls

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Tummers QR, Hoogstins CE, Gaarenstroom KN, de Kroon CD, van Poelgeest MI, Vuyk J, et al
