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GSH is a key component of cellular antioxidant defense

Moreover, inflammatory factors activate signaling pathways within endothelial cells, such as the nuclear factor-B (NF-B) pathway, further upregulating the expression of adhesion molecules (such as ICAM-1 and VCAM-1), which facilitates leukocyte adhesion and transmigration across the endothelium, thereby exacerbating BSCB damage

Annu Rev Immunol 14:649681 Beutler E, Duron O, Kelly M (1963) Colorimetric method for determination of glutathione reductase concentration